Abstract
The synthesis of 6-[3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone, N-alkyl derivatives and their cytotoxic activity in vitro against the human cell line BV-173 (chronic myeloid leukemia in lymphoblast crisis) are described. 3-Methyl-6-[3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-2(3H)-benzoxazolone as a constitutional isomer of 3-methyl-6-[3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(3H)-benzoxazolone is synthesized and its influence on cytotoxic activity is investigated.
Keywords: Chalcone, 2(3H)-benzoxazolone, Cytotoxicity
Letters in Drug Design & Discovery
Title: Synthesis of Novel Substituted 1,3-diarylpropenone Derivatives and their In Vitro Cytotoxic Activity
Volume: 6 Issue: 5
Author(s): Yordanka Ivanova, Georgi Momekov and Ognyan Petrov
Affiliation:
Keywords: Chalcone, 2(3H)-benzoxazolone, Cytotoxicity
Abstract: The synthesis of 6-[3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone, N-alkyl derivatives and their cytotoxic activity in vitro against the human cell line BV-173 (chronic myeloid leukemia in lymphoblast crisis) are described. 3-Methyl-6-[3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-2(3H)-benzoxazolone as a constitutional isomer of 3-methyl-6-[3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(3H)-benzoxazolone is synthesized and its influence on cytotoxic activity is investigated.
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Cite this article as:
Ivanova Yordanka, Momekov Georgi and Petrov Ognyan, Synthesis of Novel Substituted 1,3-diarylpropenone Derivatives and their In Vitro Cytotoxic Activity, Letters in Drug Design & Discovery 2009; 6 (5) . https://dx.doi.org/10.2174/1570180810906050353
DOI https://dx.doi.org/10.2174/1570180810906050353 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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