Scouting Novel Protein Kinase A (PKA) Inhibitors by Using a Consensus Docking-Based Virtual Screening Approach

Author(s): Nicola Zonta, Giorgio Cozza, Alessandra Gianoncelli, Oliver Korb, Thomas E. Exner, Flavio Meggio, Giuseppe Zagotto, Stefano Moro.

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 5 , 2009

Abstract:

Virtual screening (VS) approaches have been constantly increasing their applications into hit discovery process. In the last few years, we have performed an intensive screening campaign using different in silico strategies and combining them with a biochemistry validation. In the present work, using a consensus docking approach, we have identified a small family of novel protein kinase A (PKA) inhibitors. In particular, an anthraquinone derivative (compound 11) has shown an interesting inhibitory activity versus PKA with an IC50 value of 27 μM.

Keywords: Virtual screening (VS), Molecular docking, Protein kinase A (PKA)

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Article Details

VOLUME: 6
ISSUE: 5
Year: 2009
Page: [327 - 336]
Pages: 10
DOI: 10.2174/1570180810906050327
Price: $58

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