Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Ultrasound Irradiation Promoted Large-Scale Preparation in Aqueous Media and Antioxidant Activity of Azoles

Author(s): F. A.N. Silva, M. P. Galluzzi, B. Albuquerque, L. Pizzuti, V. Gressler, D. P. Rivelli, S. B.M. Barros, C. M.P. Pereira.

Abstract:

The scaled-up preparation of 1H-pyrazole, 1-phenylpyrazole and isoxazole via sonocatalysis is reported. The products were isolated in good yields in short time reaction. These compounds had been assayed for antioxidant activity by ORAC and DPPH methodologies. The results showed that only 1-phenylpyrazole presented good antioxidant activity compared with Trolox .

Keywords: Green chemistry, Isoxazole, Pyrazole, Sonocatalysis, ORAC, DPPH

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Article Details

VOLUME: 6
ISSUE: 5
Year: 2009
Page: [323 - 326]
Pages: 4
DOI: 10.2174/1570180810906050323
Price: $58