Ultrasound Irradiation Promoted Large-Scale Preparation in Aqueous Media and Antioxidant Activity of Azoles
F. A.N. Silva,
M. P. Galluzzi,
D. P. Rivelli,
S. B.M. Barros,
C. M.P. Pereira.
The scaled-up preparation of 1H-pyrazole, 1-phenylpyrazole and isoxazole via sonocatalysis is reported. The products were isolated in good yields in short time reaction. These compounds had been assayed for antioxidant activity by ORAC and DPPH methodologies. The results showed that only 1-phenylpyrazole presented good antioxidant activity compared with Trolox .
Keywords: Green chemistry, Isoxazole, Pyrazole, Sonocatalysis, ORAC, DPPH
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