A series of 30 tripeptides were synthesized and tested as novel 5-HT4 receptor ligands. Receptor binding assays showed that a subset of compounds had reasonable potency relative to the agonists serotonin and 5-methoxytryptamine. Structure-activity analyses and molecular docking have highlighted avenues for further synthetic work.
Keywords: Serotonin, 5-HT, 5-HT4, tripeptide, molecular docking, radioligand binding
Rights & PermissionsPrintExport