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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Membrane Fusion and Fission: Enveloped Viruses

Author(s): Annarita Falanga, Marco Cantisani, Carlo Pedone and Stefania Galdiero

Volume 16, Issue 7, 2009

Page: [751 - 759] Pages: 9

DOI: 10.2174/092986609788681760

Price: $65

Abstract

Membrane fusion and fission are two key processes that occur during the replication of enveloped viruses, namely access to the interior of the host-cell (entry, which requires fusion of the viral envelope with the target cell envelope) and dissemination of viral progeny after replication (egress, which involves budding and fission). These dynamic processes are mediated by specialized proteins that modify and bend the lipid bilayer transiently and locally. This review focuses on fusion and fission reactions and on the hypothetical shared mechanism that generates their driving force.

Keywords: Membrane fusion, membrane fission, glycoprotein, enveloped virus


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