Membrane Permeabilization by Multivalent Anti-Microbial Peptides

Author(s): Roland J. Pieters , Christopher J. Arnusch , Eefjan Breukink .

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 7 , 2009

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Abstract:

Antimicrobial peptides (AMPs) are promising compounds in the battle against antibiotic resistant pathogens. Many AMPs function by interacting with the bacterial membrane and selectively permeabilizing it. Improvements are desired in the potency and the in vivo stability of the AMPs. Both aspects have been approached by the preparation of multivalent versions of AMPs that contain several copies of the peptide attached to a scaffold or core molecule. Both short and long sequences have been used and in selected cases major increases in antibacterial activity, membrane permeabilization potency and in vivo stability have been obtained.

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Article Details

VOLUME: 16
ISSUE: 7
Year: 2009
Page: [736 - 742]
Pages: 7
DOI: 10.2174/092986609788681841
Price: $58

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