Cellular Efflux of cAMP and cGMP - A Question about Selectivity

Author(s): Georg Sager , Aina Westrheim Ravna .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 8 , 2009

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Abstract:

The present paper reviews and discusses selectivity of ABCC4 (MRP4), ABCC5 (MRP5) and ABCC11 (MRP8) as cellular efflux pumps for cAMP and cGMP. These transporters are potential drug targets for selective modulation of cyclic nucleotide action.

Keywords: cGMP, cAMP, ABCC4, ABCC5, ABCC11, transport selectivity

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Article Details

VOLUME: 9
ISSUE: 8
Year: 2009
Page: [1009 - 1013]
Pages: 5
DOI: 10.2174/138955709788681654
Price: $58

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