Structural and Physicochemical Profiling of Morphine and Related Compounds of Therapeutic Interest

Author(s): K. Mazak, S. Hosztafi, A. Racz, B. Noszal.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 8 , 2009

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Abstract:

A concise account of the physicochemical properties of morphine and its derivatives of therapeutic interest is provided. Such properties include macroscopic and microscopic acid/base parameters, lipophilicity, solubility, permeability that all influence the fate of drugs in the body. The dependence of these parameters on pH is discussed and subsequent implications in drug administration and formulation are presented.

Keywords: Morphine, pharmacokinetic properties, physicochemical profiling, acid/base properties, lipophilicity, solubility, permeability, stability

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Article Details

VOLUME: 9
ISSUE: 8
Year: 2009
Page: [984 - 995]
Pages: 12
DOI: 10.2174/138955709788681555
Price: $58

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