Pharmacological and Lifestyle Factors Modulating Serum Paraoxonase-1 Activity

Author(s): Jordi Camps, Judit Marsillach, Jorge Joven.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 8 , 2009

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Abstract:

Paraoxonase-1 is a lactonase and an esterase and it plays a protective role in toxicity as well as in diseases involving oxidative stress. Recently, insights into how it may be modulated by environmental factors have acquired clinical relevance. This article reviews the state-of-the-art evidence regarding PON1 modulation by pharmacological products as well as nutritional and lifestyle factors.

Keywords: Apolipoprotein A-I, fibrates, high-density lipoproteins, lipid peroxidation, nutrition, paraoxonase-1, rosiglitazone, statins

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Article Details

VOLUME: 9
ISSUE: 8
Year: 2009
Page: [911 - 920]
Pages: 10
DOI: 10.2174/138955709788681591
Price: $58

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