Mechanism of Action of Flavonoids as Anti-inflammatory Agents: A Review

Author(s): Permender Rathee, Hema Chaudhary, Sushila Rathee, Dharmender Rathee, Vikash Kumar, Kanchan Kohli.

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)

Volume 8 , Issue 3 , 2009

Abstract:

Flavonoids are polyphenolic compounds that occur ubiquitously in plants having a variety of biological effects both in vitro and in vivo. They have been found to have antimicrobial, antiviral, anti-ulcerogenic, cytotoxic, antineoplastic, mutagenic, antioxidant, antihepatotoxic, antihypertensive, hypolipidemic, antiplatelet and anti-inflammatory activities. Flavonoids also have biochemical effects, which inhibit a number of enzymes such as aldose reductase, xanthine oxidase, phosphodiesterase, Ca+2-ATPase, lipoxygenase, cycloxygenase, etc. They also have a regulatory role on different hormones like estrogens, androgens and thyroid hormone. They have been found to have anti-inflammatory activity in both proliferative and exudative phases of inflammation. Several mechanisms of action have been proposed to explain anti-inflammatory action of flavonoids. The aim of the present review is to give an overview of the mechanism of action of potential anti-inflammatory flavonoids.

Keywords: Flavonoids, inflammation, anti-inflammatory, lipoxygenases, cyclooxygenase activity

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2009
Page: [229 - 235]
Pages: 7
DOI: 10.2174/187152809788681029
Price: $58

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