Protein Engineering of a Fibroblast Growth Factor 2 Protein for Targeting to Bone Mineral Hydroxyapatite

Author(s): Eunyi Jeon, Jun-Hyeog Jang.

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 6 , 2009

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Abstract:

The engineering of a novel FGF2 fused with highly conserved bone mineral-binding domain of osteocalcin (OC) for targeting to bone mineral hydroxyapatite (HA) exhibited much stronger HA-binding affinity than native FGF2. FGF2-OC also showed a significant increase of mitogenic activity and cellular differentiation of osteoblastic cells compared with native FGF2.

Keywords: Bone, fibroblast growth factor 2, fusion, hydroxyapatite, osteocalcin

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2009
Page: [664 - 667]
Pages: 4
DOI: 10.2174/092986609788490267
Price: $65

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