Inhibitory Effects of β-Cyclodextrin and Trehalose on Nanofibril and AGE Formation During Glycation of Human Serum Albumin

Author(s): Esmaeel Sharifi, Naghmeh Sattarahmady, Mehran Habibi-Rezaei, Mohammad Farhadi, Nader Sheibani, Faizan Ahmad, Ali Akbar Moosavi-Movahedi.

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 6 , 2009

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Abstract:

The effects of β-cyclodextrin (β-CyD) and trehalose on glycation of human serum albumin (HSA) were studied. These additives reduced AGEs and nanofibril formation of HSA under in vitro glycation conditions and improved its helical structure. These were accomplished through direct interactions of them with HSA and alterations in solute-protein interactions.

Keywords: Diabetes, trehalose, β-cyclodextrin, glycation, HSA, glucose

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2009
Page: [653 - 659]
Pages: 7
DOI: 10.2174/092986609788490212
Price: $65

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