Reduced NGF Secretion by HT-29 Human Colon Cancer Cells Treated with a GRPR Antagonist

Author(s): Caroline Brunetto de Farias, Laura Stertz, Rodrigo Cruz Lima, Flavio Kapczinski, Gilberto Schwartsmann, Rafael Roesler.

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 6 , 2009

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Abstract:

The gastrin-releasing peptide receptor (GRPR) is a therapeutic target in colon cancer. Here we show that the GRPR antagonist RC-3095 (10 , 10 , or 1 μM) decreases nerve growth factor (NGF) secretion measured by enzymelinked immunosorbent assay (ELISA) in HT-29 human colon carcinoma cells. The results suggest that decreased secretion of neurotrophins might be a novel mechanism by which GRPR antagonists exert their antiproliferative effects in cancer cells.

Keywords: Gastrin-releasing peptide receptor, RC-3095, nerve growth factor, colon cancer

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2009
Page: [650 - 652]
Pages: 3
DOI: 10.2174/092986609788490177
Price: $65

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