Tethering Creates Unusual Kinetics for Ribosome-Associated Chaperones with Nascent Chains

Author(s): Stephan N. Witt.

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 6 , 2009

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Abstract:

This article focuses on ribosome-associated chaperones. A chaperone bound close to the exit tunnel on a ribosome 25 Å from the emerging nascent chain has an effective concentration of 1 x 10 M, which is 4-5 orders of magnitude larger than the concentration of the chaperone in the cytosol. Ribosome-bound chaperones bind nascent chains intramolecularly with rates as large as 10 s in order to keep chains unfolded.

Keywords: Chaperone, holdase, kinetic partitioning, proximity effect, ribosome-associated chaperone

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2009
Page: [631 - 634]
Pages: 4
DOI: 10.2174/092986609788490195
Price: $58

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