Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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Hsp70 Structure, Function, Regulation and Influence on Yeast Prions

Author(s): Deepak Sharma, Daniel C. Masison.

Abstract:

Heat shock proteins protect cells from various conditions of stress. Hsp70, the most ubiquitous and highly conserved Hsp, helps proteins adopt native conformation or regain function after misfolding. Various co-chaperones specify Hsp70 function and broaden its substrate range. We discuss Hsp70 structure and function, regulation by co-factors and influence on propagation of yeast prions.

Keywords: Hsp70, chaperone, co-chaperone, prion

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2009
Page: [571 - 581]
Pages: 11
DOI: 10.2174/092986609788490230
Price: $58