Hsp70 Structure, Function, Regulation and Influence on Yeast Prions
Deepak Sharma and Daniel C. Masison
Pages 571-581 (11)
Heat shock proteins protect cells from various conditions of stress. Hsp70, the most ubiquitous and highly conserved Hsp, helps proteins adopt native conformation or regain function after misfolding. Various co-chaperones specify Hsp70 function and broaden its substrate range. We discuss Hsp70 structure and function, regulation by co-factors and influence on propagation of yeast prions.
Hsp70, chaperone, co-chaperone, prion
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