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Protein & Peptide Letters
ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
VOLUME: 16
ISSUE: 6
DOI: 10.2174/092986609788490230      Price:  $58









Hsp70 Structure, Function, Regulation and Influence on Yeast Prions

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Author(s): Deepak Sharma and Daniel C. Masison
Pages 571-581 (11)
Abstract:
Heat shock proteins protect cells from various conditions of stress. Hsp70, the most ubiquitous and highly conserved Hsp, helps proteins adopt native conformation or regain function after misfolding. Various co-chaperones specify Hsp70 function and broaden its substrate range. We discuss Hsp70 structure and function, regulation by co-factors and influence on propagation of yeast prions.
Keywords:
Hsp70, chaperone, co-chaperone, prion
Affiliation:
Building 8, Room 407, LBG/NIDDK, National Institutes of Health, Bethesda, MD 20892-0851, USA.