Solid-Phase Synthesis of 2-Iodomethyl-2,3-dihydrobenzofurans Using Recyclable Polymer-Supported Selenium Bromide

Title: Solid-Phase Synthesis of 2-Iodomethyl-2,3-dihydrobenzofurans Using Recyclable Polymer-Supported Selenium Bromide

Volume: 6 Issue: 4

Author(s): Shouri Sheng, Minggang Hu, Dan Wu, Mingzhong Cai and Xian Huang

Affiliation:

Keywords: Solid-phase organic synthesis, Polymer-supported selenium bromide, Recyclable, Selenium mediated intramolecular cyclization, 2-Iodomethyl-2,3-dihydrobenzofuran, Traceless cleavage

Abstract: Reaction of polymer-supported selenium bromide with ortho allylated phenols and subsequent cleavage from the polymer by treatment of methyl iodide efficiently afforded 2-iodomethyl-2,3-dihydrobenzofurans in good yields and high purities. The polymeric reagent can be regenerated and reused as environmentally friendly reagent.

Cite this article as:

Sheng Shouri, Hu Minggang, Wu Dan, Cai Mingzhong and Huang Xian, Solid-Phase Synthesis of 2-Iodomethyl-2,3-dihydrobenzofurans Using Recyclable Polymer-Supported Selenium Bromide, Letters in Organic Chemistry 2009; 6 (4) . https://dx.doi.org/10.2174/157017809788489837