Synthesis and Conformational Preferences of Novel Steroidal 16-Spiro-1,3,2-Dioxaphosphorinanes

Author(s): Eva Frank, Laszlo Sipos, Janos Wolfling, Gyula Schneider.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 4 , 2009

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Abstract:

The diastereomeric pairs a and b of novel 16-spiro-dioxaphosphorinanes 3-11 were synthesised via the phosphorylation of 16,16-bis(hydroxymethyl)estrone 3-methyl ether (1) and its 17β-hydroxy analogue (2) and their stereostructures were investigated by different NMR methods.

Keywords: Steroids, spiro compounds, phosphorylations, dioxaphosphorinanes, stereostructure

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Article Details

VOLUME: 6
ISSUE: 4
Year: 2009
Page: [340 - 344]
Pages: 5
DOI: 10.2174/157017809788489927
Price: $65

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