Synthesis and Antibacterial Activities of (9S)-3-O-descladinose-6-Omethyl- 3-oxo-12-(Δ 2-pyrazolinyl)-12-dehydroxy-21-demethyl-9- dihydroerythromycin A

Author(s): Yong-Tao Wang, Lei Hu, Wei-Min Chen, Ai-Xi Hu, Qiu-Ling Song, Dong Guan.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 4 , 2009

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Abstract:

A new kind of ketolides, bearing a pyrazolinyl moiety at C-12 position, was designed and firstly synthesized starting from clarithromycin via ten steps. The title compound was evaluated for its antibacterial activities against several pathogens in vitro, and was found with potent effects on both S. aureus (ATCC6538p) and S. epidermidis (ATCC12228). The structures of new compounds were elucidated by 1HNMR, 13CNMR, MS and HRMS.

Keywords: Clarithromycin, Ketolide, Pyrazolinyl, Rearrangement, Synthesis, Antibacterial activities

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Article Details

VOLUME: 6
ISSUE: 4
Year: 2009
Page: [306 - 310]
Pages: 5
DOI: 10.2174/157017809788489918
Price: $65

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