Synthesis and Antibacterial Activities of (9S)-3-O-descladinose-6-Omethyl- 3-oxo-12-(Δ 2-pyrazolinyl)-12-dehydroxy-21-demethyl-9- dihydroerythromycin A

Title: Synthesis and Antibacterial Activities of (9S)-3-O-descladinose-6-Omethyl- 3-oxo-12-(Δ 2-pyrazolinyl)-12-dehydroxy-21-demethyl-9- dihydroerythromycin A

Volume: 6 Issue: 4

Author(s): Yong-Tao Wang, Lei Hu, Wei-Min Chen, Ai-Xi Hu, Qiu-Ling Song and Dong Guan

Affiliation:

Keywords: Clarithromycin, Ketolide, Pyrazolinyl, Rearrangement, Synthesis, Antibacterial activities

Abstract: A new kind of ketolides, bearing a pyrazolinyl moiety at C-12 position, was designed and firstly synthesized starting from clarithromycin via ten steps. The title compound was evaluated for its antibacterial activities against several pathogens in vitro, and was found with potent effects on both S. aureus (ATCC6538p) and S. epidermidis (ATCC12228). The structures of new compounds were elucidated by 1HNMR, 13CNMR, MS and HRMS.

Cite this article as:

Wang Yong-Tao, Hu Lei, Chen Wei-Min, Hu Ai-Xi, Song Qiu-Ling and Guan Dong, Synthesis and Antibacterial Activities of (9S)-3-O-descladinose-6-Omethyl- 3-oxo-12-(Δ 2-pyrazolinyl)-12-dehydroxy-21-demethyl-9- dihydroerythromycin A, Letters in Organic Chemistry 2009; 6 (4) . https://dx.doi.org/10.2174/157017809788489918