Effects of Ionic Liquids for Lipase-Catalyzed Chiral 1,1-binaphthyl-2- yl(phenyl)methanone O-acetyl Oxime Synthesis

Author(s): Yongchang Zhou, Motohiro Takahashi, Naoto Aoyagi, Chunlei Li, Tatsuro Kijima, Taeko Izumi.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 4 , 2009

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Abstract:

The resolution of 1,1-binaphthyl-2-yl(phenyl)methanone O-acetyl oxime catalyzed by lipase in three different ionic liquids, 1-butyl-3-methylimidazolium hexafluoride-phosphate, [bmim][PF6], 1-butyl-3-methylimidazolium tetrafluoroborate, [bmim][BF4] and N-butyl-pyridium hexafluorophosphate, [BuPy][PF6] and organic solvents was studied. The lipase shows low activity in ionic liquids and organic solvent with ionic liquids as the additive, while the lipase coated with ionic liquids gives the best enantioselectivity as high as 95 %.

Keywords: Ionic liquids, Lipase-catalyzed, Chiral, O-acetyl oxime, Synthesis, Resolution

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Article Details

VOLUME: 6
ISSUE: 4
Year: 2009
Page: [297 - 300]
Pages: 4
DOI: 10.2174/157017809788489864
Price: $65

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