First Synthesis of Lissoclimide-Type Alkaloids

Author(s): Miguel A. Gonzalez, Damaris Romero, Bibiana Zapata, Liliana Betancur-Galvis.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 4 , 2009

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Abstract:

The first synthesis of lissoclimide-type alkaloids is described. Starting from commercial (+)-sclareolide, the aldehyde γ-bicyclohomofarnesal is synthesized and coupled, through an aldol reaction, with succinimide. The antitumor activity of several lissoclimide analogues is also reported.

Keywords: Lissoclimide, Haterumaimide, Diterpene, Alkaloid, Cytotoxicity, Aldol

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Article Details

VOLUME: 6
ISSUE: 4
Year: 2009
Page: [289 - 292]
Pages: 4
DOI: 10.2174/157017809788489828
Price: $65

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