Title: The Insulin-like Growth Factor-1 Axis and its Potential as a Therapeutic Target in Central Nervous System (CNS) Disorders
VOLUME: 9 ISSUE: 2
Author(s):Olivia Bibollet-Bahena, Qiao-Ling Cui and Guillermina Almazan
Affiliation:Department of Pharmacology and Therapeutics, McGill University 3655 Promenade Sir-William-Osler, Room 1321 Montreal, Quebec H3G 1Y6 (Canada).
Abstract: The insulin-like growth factor-1 (IGF-1) is a pleiotropic factor. Many studies have revealed its importance in the development and maintenance of the central nervous system (CNS). This review will discuss the IGF-1 axis, from the factor itself to the signalling pathways it activates, and its tight regulation. Particular focus will be brought on potential therapeutic targets of the IGF-1 axis in CNS disorders, including brain tumours and neurodegenerative diseases affecting neurons and oligodendrocytes.
