Current Considerations for the Effective Safety Evaluation of Drugs In Vitro

Author(s): Jinsheng Xu, Simon K. Jackson.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 7 , 2009

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Abstract:

As the traditional in vivo tests are gradually shifting into in vitro tests, some new issues become apparent. This review discusses the essential considerations in endpoint selection, cell model quality, exposure concentration and linking factors between in vitro and in vivo studies in using in vitro models in risk assessment.

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Article Details

VOLUME: 9
ISSUE: 7
Year: 2009
Page: [861 - 868]
Pages: 8
DOI: 10.2174/138955709788452577
Price: $58

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