D-Serine Regulation: A Possible Therapeutic Approach for Central Nervous Diseases and Chronic Pain

Author(s): R. Sethuraman, T. L. Lee, S. Tachibana.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 7 , 2009

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Abstract:

D-Serine, an endogenous modulator of NMDA receptors has been shown to play a vital role in many neuropsychiatric functions such as learning, memory, nociception and implicated in pathological conditions like schizophrenia and Alzheimers disease. We propose possible therapeutic approaches for some CNS diseases and chronic pain, targeting the D-serine levels by manipulating its uptake, biosynthesis and metabolism.

Keywords: D-Serine, NMDA receptors, CNS diseases, chronic pain, serine racemase, D-amino acid oxidase, amino acid transporters

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Article Details

VOLUME: 9
ISSUE: 7
Year: 2009
Page: [813 - 819]
Pages: 7
DOI: 10.2174/138955709788452630
Price: $58

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