New Insights into the Pleiotropic Effects of Statins for Stroke Prevention

Author(s): Alessandro Pezzini, Elisabetta Del Zotto, Irene Volonghi, Alessia Giossi, Paolo Costa, Alessandro Padovani.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 7 , 2009

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Abstract:

There is compelling evidence that treatment with 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors - “statins” - the most important class of lipid lowering agents, reduces ischemic stroke incidence independent on their effect on serum cholesterol levels. In this review, the non-lipid-mediated - “pleiotropic” - effects of statins as well as their potential implication in developing new treatment strategies for stroke prevention will be discussed.

Keywords: HMG-CoA reductase inhibitors, stroke, pleiotropic effects

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Article Details

VOLUME: 9
ISSUE: 7
Year: 2009
Page: [794 - 804]
Pages: 11
DOI: 10.2174/138955709788452658
Price: $58

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