Thalidomide Chemotherapy-Induced Peripheral Neuropathy: Actual Status and New Perspectives with Thalidomide Analogues Derivatives

Author(s): Sante Cundari, Guido Cavaletti.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 7 , 2009

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Abstract:

IMiDs compounds are a class of analogues of thalidomide, with greater immunomodulatory activity and a superior safety profile compared to the parent compound. They show substantial increase in potency and an interesting tolerability profile, primarily due to a decreased incidence of the most severe side effect of thalidomide, i.e. Chemotherapy- Induced Peripheral Neurotoxicity (CIPN). These novel aspects of the IMiDs compounds will be discussed.

Keywords: IMiDs, thalidomide, CC-5013, lenalidomide, CC-4047, pomalidomide, safety, side effects, CIPN

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Article Details

VOLUME: 9
ISSUE: 7
Year: 2009
Page: [760 - 768]
Pages: 9
DOI: 10.2174/138955709788452595
Price: $58

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