Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Biological Evaluation of a Series of 4-(arylamido/imidoalkyl)- 5-(arylideno- 4-oxo-2-thio-imidazolidinyl)-N-(methyl-phenyl-imino) Acridinium Iodides as Potential Antiviral Agents

Author(s): Abha Bishnoi, Rashmi Saxena, Suruchi Singh, Archna Rani, M. N. Joshi, S. K. Bajpai.

Abstract:

Compounds (5a-5f) containing acridine and imidazole moieties in one molecular union were synthesized, characterized and screened against Japanese Encephalitis virus (JEV) (P 20778) and Herpes Simplex virus type-1 (HSV-1) (753166) in-vitro and in-vivo, both. Compound (5e) exhibited the highest activity against both the test microbe (50% inhibition) while (5a) was moderately active (30% inhibition).Compound (5f) displayed 40% inhibition of HSV-1. Investigation revealed that 2-hydroxyphenyl substituent at position-4 is a key factor for bioactivity.

Keywords: Acridinium iodides, Imidazole, Acetophenones, Amido-alkylated acridines, Anti-JEV activity, Anti HSV-I activity

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Article Details

VOLUME: 6
ISSUE: 4
Year: 2009
Page: [252 - 257]
Pages: 6
DOI: 10.2174/157018009788452500
Price: $58