Pharmacology of the Intracellular Pathways Activated by Amyloid Beta Protein

Author(s): Hugo Balleza-Tapia, Fernando Pena.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 6 , 2009

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Abstract:

Alzheimers disease (AD) is a late-life cognitive disorder associated, among other things, to the presence of extracellular aggregates of fibrillar amyloid beta protein (Aβ). However, there is growing evidence that early stages of AD may be due to neuronal network dysfunction produced by the actions of soluble forms of Aβ. Therefore, the development of new therapeutic strategies to treat AD, at least during its first stages, may be focused on preventing or reversing, the deleterious effects that soluble Aβ exerts on neuronal circuit function. In order to do so, it is necessary to elucidate the pathophysiological processes involved in Aβ-induced neuronal network dysfunction and the molecular processes underlying such dysfunction. Over the last decades, there has been extensive research about the molecular mechanisms involved in the effects of Aβ as well as possible neuroprotective strategies against such effects. Here we are going to review some of the intracellular pathways triggered by Aβ, which involve membrane receptors such as nicotinic-R, NMDA-R, integrins, TNF-R1, RAGE, FPRL and p75NTR and their intracellular mediators such as GSK3, PKC, PI3K, Akt, FAK, MAPK family, Src family and cdk5. Several of these pathways may constitute therapeutic targets for the treatment of the Aβ-induced neuronal network dysfunction which is, at least in part, the basis for cognitive dysfunction in AD.

Keywords: Alzheimer's disease, Aβ-signaling pathways, neuronal network dysfunction, Aβ-related receptors and pharmacological targets

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2009
Page: [724 - 740]
Pages: 17
DOI: 10.2174/138955709788452784
Price: $58

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