The Role of Parathyroid Hormone-Related Protein (PTHrP) in the Pathophysiology of Diabetes Mellitus

Author(s): Ioannis Legakis.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 6 , 2009

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Abstract:

Type 2 diabetes is characterized by hyperglycemia resulting from insulin resistance in the setting of inadequate beta-cell compensation. Impaired beta-cell function and possibly beta-cell mass appear to be reversible, particularly at early stages of the disease. Pancreatic beta-cells possess the potential to greatly expand their function and mass in both physiologic and pathologic states by several mechanisms, including hypertrophy and proliferation of existing beta-cells, increased insulin production and secretion, and formation of new beta-cells from progenitor cells. Recently a large number of factors controlling the differentiation of beta-cells has been identified and among them the parathyroid hormone-related protein (PTHrP) emerged as a strong candidate in ß-cell survival. In this review, we will hightlight our current knowledge in PTHrP physiology implicating its role into the mechanisms of beta-cell mass regulation and consequently in diabetes. Further research into mechanisms will reveal the key modulators of beta-cell failure and thus identify possible novel therapeutic targets.

Keywords: Parathyroid hormone-related protein (PTHrP), diabetes, ß-cell survival, glucose homeostasis

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2009
Page: [717 - 723]
Pages: 7
DOI: 10.2174/138955709788452766
Price: $58

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