The Complement Cascade: New Avenues in Stroke Therapy

Author(s): Ricardo J. Komotar, Robert M. Starke, Eric J. Arias, Matthew C. Garrett, Marc L. Otten, Maxwell B. Merkow, Benjamin Hassid, J. Mocco, Michael E. Sughrue, Grace H. Kim, William J. Mack, Andrew F. Ducruet, E. Sander Connolly.

Journal Name: Current Vascular Pharmacology

Volume 7 , Issue 3 , 2009

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Abstract:

Recent evidence has shown that after the initial occlusion, a large portion of stroke patients achieve some degree of reperfusion either through collateral circulation or clot dissolution. However, it appears that this reperfusion may lead to increased inflammation-induced damage. Even though the exact mechanism of this secondary injury is unclear, several experimental studies have indicated an intimate connection between complement and this secondary form of damage. We review the available literature and attempt to identify promising clinical therapeutic targets.

Keywords: Complement, stroke, reperfusion, ischemia

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2009
Page: [287 - 292]
Pages: 6
DOI: 10.2174/157016109788340677
Price: $58

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