Voltage-Gated Sodium Channel Blockers for the Treatment of Chronic Pain

Author(s): Mark A. Matulenko, Marc J. C. Scanio, Michael E. Kort.

Journal Name: Current Topics in Medicinal Chemistry

Volume 9 , Issue 4 , 2009

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Abstract:

The voltage-gated sodium channels are a family of proteins that control the flow of sodium ions across cell membranes. Considerable data support the hypothesis that hyperexcitability and spontaneous action potential firing in peripheral sensory neurons mediated by voltage-gated sodium channels contribute to the pathophysiology of chronic pain. Sodium channel blockers are, therefore, appealing entities for therapeutic intervention in painful human neuropathies. This review will focus on the latest advances in the development of small molecule sodium channel blockers and their application to the treatment of chronic pain.

Keywords: Sodium channel, voltage-gated, blocker, selective, pain

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Article Details

VOLUME: 9
ISSUE: 4
Year: 2009
Page: [362 - 376]
Pages: 15
DOI: 10.2174/156802609788317883
Price: $65

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