Synthesis of the α-Tocopheramine-15N Model Compound 2,2,5,7,8- Pentamethyl-6-chromanylamine-15N

Title: Synthesis of the α-Tocopheramine-15N Model Compound 2,2,5,7,8- Pentamethyl-6-chromanylamine-15N

Volume: 7 Issue: 4

Author(s): Stefan Bohmdorfer, Lars Gille and Thomas Rosenau

Affiliation:

Keywords: Tocopherols, tocopheramine, vitamin E, isotopic labeling, chromans

Abstract: 2,2,5,7,8-Pentamethyl-6-chromanylamine-15N was prepared by condensation of ZnCl2-catalyzed condensation of 2,3,5-trimethylphenol with isoprene, followed by conversion of the resulting chroman into the 6-nitro-derivative and further reduction to the title compound, which possesses a 2-methyl group instead of the isoprenoid side chain of tocopherols and tocopheramines. Tocopheramines and their short-chain analogues are current targets in medicinal chemistry and anti-cancer research.

Cite this article as:

Bohmdorfer Stefan, Gille Lars and Rosenau Thomas, Synthesis of the α-Tocopheramine-15N Model Compound 2,2,5,7,8- Pentamethyl-6-chromanylamine-15N, Letters in Organic Chemistry 2010; 7 (4) . https://dx.doi.org/10.2174/157017810791130612