Synthesis of the α-Tocopheramine-15N Model Compound 2,2,5,7,8- Pentamethyl-6-chromanylamine-15N

Author(s): Stefan Bohmdorfer, Lars Gille, Thomas Rosenau.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 4 , 2010

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2,2,5,7,8-Pentamethyl-6-chromanylamine-15N was prepared by condensation of ZnCl2-catalyzed condensation of 2,3,5-trimethylphenol with isoprene, followed by conversion of the resulting chroman into the 6-nitro-derivative and further reduction to the title compound, which possesses a 2-methyl group instead of the isoprenoid side chain of tocopherols and tocopheramines. Tocopheramines and their short-chain analogues are current targets in medicinal chemistry and anti-cancer research.

Keywords: Tocopherols, tocopheramine, vitamin E, isotopic labeling, chromans

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Article Details

Year: 2010
Page: [335 - 337]
Pages: 3
DOI: 10.2174/157017810791130612
Price: $65

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