Diphenylammonium Triflate: A Novel and Efficient Catalyst for Synthesis of Spiro-Heterocyclic Compounds

Author(s): Jianjun Li, Jian Sun, Weike Su.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 4 , 2010

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A general and practical one-pot synthesis of spiro-heterocyclic compounds using diphenylammonium triflate (DPAT, 5 mol%) as a novel and efficient catalyst is described. The pseudo four-components Biginelli-like reaction of 5,5- dimethyl-1,3-cyclohexanedione, thiourea and aldehydes catalyzed by DPAT in refluxing ethanol produced the corresponding spiro-heterocyclic compounds with moderate to good yields. A possible mechanism is proposed.

Keywords: Biginelli-type reaction, spiro-heterocyclic compounds, catalyst, diphenylammonium triflate

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Article Details

Year: 2010
Page: [314 - 318]
Pages: 5
DOI: 10.2174/157017810791130630
Price: $65

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