A general and practical one-pot synthesis of spiro-heterocyclic compounds using diphenylammonium triflate (DPAT, 5 mol%) as a novel and efficient catalyst is described. The pseudo four-components Biginelli-like reaction of 5,5- dimethyl-1,3-cyclohexanedione, thiourea and aldehydes catalyzed by DPAT in refluxing ethanol produced the corresponding spiro-heterocyclic compounds with moderate to good yields. A possible mechanism is proposed.
Keywords: Biginelli-type reaction, spiro-heterocyclic compounds, catalyst, diphenylammonium triflate
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