One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate

Author(s): Dina Scarpi, Ernesto G. Occhiato, Antonio Guarna, Valerio Borzatta.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 4 , 2010

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Abstract:

A new method is reported for the preparation of 2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester, a key intermediate in the synthesis of Tadalafil which is used for the treatment of male erectile dysfunction, via one-pot esterification and Pictet-Spengler reaction.

Keywords: Pictet-Spengler, esterification, isomerization, Tadalafil

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2010
Page: [311 - 313]
Pages: 3
DOI: 10.2174/157017810791130667
Price: $65

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