One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate

Title: One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate

Volume: 7 Issue: 4

Author(s): Dina Scarpi, Ernesto G. Occhiato, Antonio Guarna and Valerio Borzatta

Affiliation:

Keywords: Pictet-Spengler, esterification, isomerization, Tadalafil

Abstract: A new method is reported for the preparation of 2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester, a key intermediate in the synthesis of Tadalafil which is used for the treatment of male erectile dysfunction, via one-pot esterification and Pictet-Spengler reaction.

Cite this article as:

Scarpi Dina, G. Occhiato Ernesto, Guarna Antonio and Borzatta Valerio, One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate, Letters in Organic Chemistry 2010; 7 (4) . https://dx.doi.org/10.2174/157017810791130667