Triethylamine Promoted Efficient Synthesis of 3,4-Dihydropyrimidin- 2(1H)-ones/thiones Using a Solvent-Free Biginelli Condensation

Author(s): Abdelmadjid Debache, Wassima Ghalem, Raouf Boulcina, Ali Belfaitah, Salah Rhouati, Bertrand Carboni.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 4 , 2010

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An efficient and simple protocol has been developed for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by a one-pot three-component cyclocondensation reaction of an aromatic aldehyde, β-ketoester, and urea or thiourea under solvent-free conditions using triethylamine (Et3N) as catalyst for the Biginelli reaction.

Keywords: Triethylamine, Bronsted bases, multicomponent reaction, 3,4-dihydropyrimidin-2(1H)-ones/thiones, Biginelli reaction, one-pot condensation

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Article Details

Year: 2010
Page: [272 - 276]
Pages: 5
DOI: 10.2174/157017810791130595
Price: $65

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