Abstract
Pseudogenes are homologous relatives of known genes that have lost their ability to function as a transcriptional unit. Three classes of pseudogenes are known to exist: duplicated pseudogenes; processed or retrotransposed pseudogenes; and unitary or disabled pseudogenes. Since pseudogenes may display a number of the characteristics of functional genes, they pose a unique set of problems for ab initio gene prediction. The ability to detect and differentiate pseudogenes from functional genes can be a difficult task. We present a comprehensive review of current approaches for pseudogene detection, highlighting difficulties in pseudogene differentiation.
Keywords: Pseudogene, gene prediction, disabled pseudogenes, processed pseudogenes, duplicated pseudogenes
Current Bioinformatics
Title: Current Trends in Pseudogene Detection and Characterization
Volume: 4 Issue: 2
Author(s): Eric Christian Rouchka and I. Elizabeth Cha
Affiliation:
Keywords: Pseudogene, gene prediction, disabled pseudogenes, processed pseudogenes, duplicated pseudogenes
Abstract: Pseudogenes are homologous relatives of known genes that have lost their ability to function as a transcriptional unit. Three classes of pseudogenes are known to exist: duplicated pseudogenes; processed or retrotransposed pseudogenes; and unitary or disabled pseudogenes. Since pseudogenes may display a number of the characteristics of functional genes, they pose a unique set of problems for ab initio gene prediction. The ability to detect and differentiate pseudogenes from functional genes can be a difficult task. We present a comprehensive review of current approaches for pseudogene detection, highlighting difficulties in pseudogene differentiation.
Export Options
About this article
Cite this article as:
Rouchka Christian Eric and Cha Elizabeth I., Current Trends in Pseudogene Detection and Characterization, Current Bioinformatics 2009; 4 (2) . https://dx.doi.org/10.2174/157489309788184792
DOI https://dx.doi.org/10.2174/157489309788184792 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Effects of LPA and S1P on the Nervous System and Implications for Their Involvement in Disease
Current Drug Targets Application of Radiolabeled Antibodies in Targeting Therapy of Breast Cancer
Current Molecular Imaging (Discontinued) Animal Mitochondria: Evolution, Function, and Disease
Current Molecular Medicine Current Advances and Therapeutic Potential of Agents Targeting Dipeptidyl Peptidases-IV, -II, 8/9 and Fibroblast Activation Protein
Current Topics in Medicinal Chemistry PROGRAMMED Cell Clearance: Molecular Mechanisms and Role in Autoimmune Disease, Chronic Inflammation, and Anti-Cancer Immune Responses
Current Immunology Reviews (Discontinued) Targeting the Progression of Parkinsons Disease
Current Neuropharmacology Recent Advances in the Development of Novel Therapeutics Targeting Dendritic Cells
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery The Role of Melatonin in Multiple Sclerosis, Huntington's Disease and Cerebral Ischemia
CNS & Neurological Disorders - Drug Targets Apoptosis and Autophagy Induction As Mechanism of Cancer Prevention by Naturally Occurring Dietary Agents
Current Drug Targets Risk Assessment of the Use of Autonomous Parvovirus-Based Vectors
Current Gene Therapy Multifaceted Approach to Circadian Rhythm: Redox, Oxidative Stress, Melatonin, Antioxidants, Nitric Oxide, Hypoxia, Anesthetics, Cortisol and Cocaine
Current Chemical Biology Protein Phosphatase 2A as a Potential Target for Treatment of Adult T Cell Leukemia
Current Cancer Drug Targets MDM2 Increases Drug Resistance in Cancer Cells by Inducing EMT Independent of p53
Current Medicinal Chemistry Androgen Receptor in Human Health: A Potential Therapeutic Target
Current Drug Targets Zoledronate Induced Hypocalcemia and Hypophosphatemia in Osteoporosis: A Cause of Concern
Current Drug Safety A Co-Module Regulated by Therapeutic Drugs in a Molecular Subnetwork of Alzheimer’s Disease Identified on the Basis of Traditional Chinese Medicine and SAMP8 Mice
Current Alzheimer Research The Anti-Breast Cancer Effects of Green-Synthesized Zinc Oxide Nanoparticles Using Carob Extracts
Anti-Cancer Agents in Medicinal Chemistry The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson's Disease Model
CNS & Neurological Disorders - Drug Targets KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions
Current Genomics Computational and Statistical Methods to Explore the Various Dimensions of Protein Evolution
Current Bioinformatics