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Current Bioinformatics

Editor-in-Chief

ISSN (Print): 1574-8936
ISSN (Online): 2212-392X

Current Trends in Pseudogene Detection and Characterization

Author(s): Eric Christian Rouchka and I. Elizabeth Cha

Volume 4, Issue 2, 2009

Page: [112 - 119] Pages: 8

DOI: 10.2174/157489309788184792

Price: $65

Abstract

Pseudogenes are homologous relatives of known genes that have lost their ability to function as a transcriptional unit. Three classes of pseudogenes are known to exist: duplicated pseudogenes; processed or retrotransposed pseudogenes; and unitary or disabled pseudogenes. Since pseudogenes may display a number of the characteristics of functional genes, they pose a unique set of problems for ab initio gene prediction. The ability to detect and differentiate pseudogenes from functional genes can be a difficult task. We present a comprehensive review of current approaches for pseudogene detection, highlighting difficulties in pseudogene differentiation.

Keywords: Pseudogene, gene prediction, disabled pseudogenes, processed pseudogenes, duplicated pseudogenes


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