Current Bioinformatics

Yi-Ping Phoebe Chen
Department of Computer Science and Information Technology
La Trobe University
Melbourne
Australia

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Current Trends in Pseudogene Detection and Characterization

Author(s): Eric Christian Rouchka, I. Elizabeth Cha.

Abstract:

Pseudogenes are homologous relatives of known genes that have lost their ability to function as a transcriptional unit. Three classes of pseudogenes are known to exist: duplicated pseudogenes; processed or retrotransposed pseudogenes; and unitary or disabled pseudogenes. Since pseudogenes may display a number of the characteristics of functional genes, they pose a unique set of problems for ab initio gene prediction. The ability to detect and differentiate pseudogenes from functional genes can be a difficult task. We present a comprehensive review of current approaches for pseudogene detection, highlighting difficulties in pseudogene differentiation.

Keywords: Pseudogene, gene prediction, disabled pseudogenes, processed pseudogenes, duplicated pseudogenes

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2009
Page: [112 - 119]
Pages: 8
DOI: 10.2174/157489309788184792
Price: $58