SELDI Protein Chip Technology for the Detection of Serum Biomarkers for Liver Disease
Lei Chen, Sarwat Fatima, Jirun Peng and Xisheng Leng
Affiliation: Department of Hepatobiliary Surgery, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, 100044, P.R. China.
The need to identify disease biomarkers is critical to ensure fast diagnosis and timely treatment. Surface enhanced laser desorption/ionization time-of-fight mass spectrometry (SELDI-TOF-MS) is a widely used technology platform for diagnostic biomarker discovery. This short review provides an overview of how it functions and also describes its advantages and drawbacks.
Keywords: Surface enhanced laser desorption/ionization, proteomics, biomarker, liver diseases
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