Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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SELDI Protein Chip Technology for the Detection of Serum Biomarkers for Liver Disease

Author(s): Lei Chen, Sarwat Fatima, Jirun Peng and Xisheng Leng

Affiliation: Department of Hepatobiliary Surgery, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, 100044, P.R. China.

Abstract:

The need to identify disease biomarkers is critical to ensure fast diagnosis and timely treatment. Surface enhanced laser desorption/ionization time-of-fight mass spectrometry (SELDI-TOF-MS) is a widely used technology platform for diagnostic biomarker discovery. This short review provides an overview of how it functions and also describes its advantages and drawbacks.

Keywords: Surface enhanced laser desorption/ionization, proteomics, biomarker, liver diseases

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Article Details

VOLUME: 16
ISSUE: 5
Page: [467 - 472]
Pages: 6
DOI: 10.2174/092986609788167851
Price: $58