Second-Generation Histamine H2-Receptor Antagonists with Gastric Mucosal Defensive Properties

Author(s): Takafumi Ichikawa, Kyoko Hotta, Kazuhiko Ishihara.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 5 , 2009

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Abstract:

Unlike the earlier agents in this class, certain of the newer histamine HB2B-receptor antagonists (so-called secondgeneration HB2B-receptor antagonists) have recently been reported to promote gastric mucosal defenses. We review herein the structure, specificity, and mechanisms of these agents with a special focus on their cytoprotective/gastroprotective actions.

Keywords: Calcitonin gene-related peptide (CGRP), capsaicin-sensitive nerves, gastroprotective action, histamine HB2B-receptor antagonists, lafutidine, mucin, roxatidine, structure-activity relationship

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Article Details

VOLUME: 9
ISSUE: 5
Year: 2009
Page: [581 - 589]
Pages: 9
DOI: 10.2174/138955709788167646
Price: $58

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