Diphenylpentane Skeleton as a Multi-Template for Steroid Skeleton- Recognizing Receptors/Enzymes

Author(s): Shinnosuke Hosoda , Daisuke Matsuda , Hiroshi Tomoda , Yuichi Hashimoto .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 5 , 2009

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Abstract:

As an example of a multi-template approach, we focused on the 3,3-diphenylpentane (DPP) skeleton, which has been demonstrated to act as a steroid skeleton substitute. Various ligands for nuclear receptors (NRs), including vitamin D receptor (VDR), androgen receptor (AR) and farnesoid X receptor (FXR), and inhibitors of steroid metabolismrelated enzymes, including 5α-reductase and HMG-CoA reductase (HMGR), have been efficiently created by introducing various substituents onto the DPP skeleton.

Keywords: Multi-template, steroids, diphenylpentane skeleton, steroid skeleton substitute, nuclear receptor, vitamin D receptor, androgen receptor, farnesoid X receptor, 5α-reductase, HMG-CoA reductase

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Article Details

VOLUME: 9
ISSUE: 5
Year: 2009
Page: [572 - 580]
Pages: 9
DOI: 10.2174/138955709788167574
Price: $58

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