Abstract
Drugs which inhibit epidermal growth factor receptor (EGFR) are used in the treatment of cancers. EGFR may contribute to the development of hypertension by regulating vascular tone and renal Na+ handling. Synthetic EGFR inhibitors reduce blood pressure in some experimental models of hypertension suggesting that this receptor is a novel target for antihypertensive therapy.
Keywords: Epidermal growth factor receptor, arterial hypertension, receptor transactivation, extracellular signal-regulated kinases, receptor tyrosine kinase inhibitors, leptin, metabolic syndrome
Mini-Reviews in Medicinal Chemistry
Title: EGF Receptor as a Drug Target in Arterial Hypertension
Volume: 9 Issue: 5
Author(s): J. Beltowski and E. Lowicka
Affiliation:
Keywords: Epidermal growth factor receptor, arterial hypertension, receptor transactivation, extracellular signal-regulated kinases, receptor tyrosine kinase inhibitors, leptin, metabolic syndrome
Abstract: Drugs which inhibit epidermal growth factor receptor (EGFR) are used in the treatment of cancers. EGFR may contribute to the development of hypertension by regulating vascular tone and renal Na+ handling. Synthetic EGFR inhibitors reduce blood pressure in some experimental models of hypertension suggesting that this receptor is a novel target for antihypertensive therapy.
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Cite this article as:
Beltowski J. and Lowicka E., EGF Receptor as a Drug Target in Arterial Hypertension, Mini-Reviews in Medicinal Chemistry 2009; 9 (5) . https://dx.doi.org/10.2174/138955709788167619
DOI https://dx.doi.org/10.2174/138955709788167619 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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