Mini-Reviews in Medicinal Chemistry


EGF Receptor as a Drug Target in Arterial Hypertension

Author(s): J. Beltowski and E. Lowicka

Affiliation: Department of Pathophysiology, Medical University, ul. Jaczewskiego 8, 20-090 Lublin, Poland.


Drugs which inhibit epidermal growth factor receptor (EGFR) are used in the treatment of cancers. EGFR may contribute to the development of hypertension by regulating vascular tone and renal Na+ handling. Synthetic EGFR inhibitors reduce blood pressure in some experimental models of hypertension suggesting that this receptor is a novel target for antihypertensive therapy.

Keywords: Epidermal growth factor receptor, arterial hypertension, receptor transactivation, extracellular signal-regulated kinases, receptor tyrosine kinase inhibitors, leptin, metabolic syndrome

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Article Details

Page: [526 - 538]
Pages: 13
DOI: 10.2174/138955709788167619
Price: $58