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Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
VOLUME: 9
ISSUE: 5
DOI: 10.2174/138955709788167619      Price:  $58









EGF Receptor as a Drug Target in Arterial Hypertension

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Author(s): J. Beltowski and E. Lowicka
Pages 526-538 (13)
Abstract:
Drugs which inhibit epidermal growth factor receptor (EGFR) are used in the treatment of cancers. EGFR may contribute to the development of hypertension by regulating vascular tone and renal Na+ handling. Synthetic EGFR inhibitors reduce blood pressure in some experimental models of hypertension suggesting that this receptor is a novel target for antihypertensive therapy.
Keywords:
Epidermal growth factor receptor, arterial hypertension, receptor transactivation, extracellular signal-regulated kinases, receptor tyrosine kinase inhibitors, leptin, metabolic syndrome
Affiliation:
Department of Pathophysiology, Medical University, ul. Jaczewskiego 8, 20-090 Lublin, Poland.