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EGF Receptor as a Drug Target in Arterial Hypertension

Author(s): J. Beltowski and E. Lowicka

Affiliation: Department of Pathophysiology, Medical University, ul. Jaczewskiego 8, 20-090 Lublin, Poland.

Abstract:

Drugs which inhibit epidermal growth factor receptor (EGFR) are used in the treatment of cancers. EGFR may contribute to the development of hypertension by regulating vascular tone and renal Na+ handling. Synthetic EGFR inhibitors reduce blood pressure in some experimental models of hypertension suggesting that this receptor is a novel target for antihypertensive therapy.

Keywords: Epidermal growth factor receptor, arterial hypertension, receptor transactivation, extracellular signal-regulated kinases, receptor tyrosine kinase inhibitors, leptin, metabolic syndrome

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Article Details

VOLUME: 9
ISSUE: 5
Page: [526 - 538]
Pages: 13
DOI: 10.2174/138955709788167619
Price: $58