Chemotherapeutic Properties of n-3 Polyunsaturated Fatty Acids - Old Concepts and New Insights

Author(s): Wooki Kim, David N. McMurray, Robert S. Chapkin.

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)

Volume 9 , Issue 1 , 2009

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Abstract:

Over the past several decades, data from both experimental animal studies and human clinical trials have shown that dietary n-3 polyunsaturated fatty acids (PUFA) exhibit anti-inflammatory bioactive properties, compared to n- 6 PUFA. Collectively, these studies have identified multiple mechanisms by which n-3 PUFA affect immune cell responses. In this review, we discuss the putative targets of anti-inflammatory n-3 PUFA, specifically, cytokine production, antagonism of n-6 PUFA metabolism, binding to nuclear receptors as ligands, and the alteration of signaling protein acylation. In addition, we investigate the effect of n-3 PUFA on the coalescence of lipid rafts, specialized signaling platforms in the plasma membrane.

Keywords: Diet, n-3 PUFA, chronic inflammation, CD4+ T-cells

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2009
Page: [38 - 44]
Pages: 7
DOI: 10.2174/187152209788009841

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