Novel Detection System for Plant Protein Production of Pharmaceuticals and Impact on Conformational Diseases

Author(s): Kerstin A. Nagel, Bernd Kastenholz, Frank Gilmer, Ulrich Schurr, Achim Walter.

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 6 , 2010

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Abstract:

State-of-the-art biochemistry methods in combination with an automated phenotyping method demonstrate the high potential of transgenic tobacco plants in producing properly-folded therapeutic proteins for the treatment of protein-misfolding diseases (e.g., Alzheimers disease). This molecular farming approach led to highest protein production of hydroponically- grown tobacco compared to other growth substrates generally used in plant cultivation.

Keywords: Protein folding, Alzheimer's disease, molecular farming, PMPs, value-added biochemicals, methodologial strategy

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Article Details

VOLUME: 17
ISSUE: 6
Year: 2010
Page: [723 - 731]
Pages: 9
DOI: 10.2174/092986610791190282
Price: $58

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