Abstract
State-of-the-art biochemistry methods in combination with an automated phenotyping method demonstrate the high potential of transgenic tobacco plants in producing properly-folded therapeutic proteins for the treatment of protein-misfolding diseases (e.g., Alzheimers disease). This molecular farming approach led to highest protein production of hydroponically- grown tobacco compared to other growth substrates generally used in plant cultivation.
Keywords: Protein folding, Alzheimer's disease, molecular farming, PMPs, value-added biochemicals, methodologial strategy
Protein & Peptide Letters
Title: Novel Detection System for Plant Protein Production of Pharmaceuticals and Impact on Conformational Diseases
Volume: 17 Issue: 6
Author(s): Kerstin A. Nagel, Bernd Kastenholz, Frank Gilmer, Ulrich Schurr and Achim Walter
Affiliation:
Keywords: Protein folding, Alzheimer's disease, molecular farming, PMPs, value-added biochemicals, methodologial strategy
Abstract: State-of-the-art biochemistry methods in combination with an automated phenotyping method demonstrate the high potential of transgenic tobacco plants in producing properly-folded therapeutic proteins for the treatment of protein-misfolding diseases (e.g., Alzheimers disease). This molecular farming approach led to highest protein production of hydroponically- grown tobacco compared to other growth substrates generally used in plant cultivation.
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Cite this article as:
A. Nagel Kerstin, Kastenholz Bernd, Gilmer Frank, Schurr Ulrich and Walter Achim, Novel Detection System for Plant Protein Production of Pharmaceuticals and Impact on Conformational Diseases, Protein & Peptide Letters 2010; 17 (6) . https://dx.doi.org/10.2174/092986610791190282
DOI https://dx.doi.org/10.2174/092986610791190282 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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