Homology Modeling Studies of Yeast Mitogen-Activated Protein Kinases (MAPKS): Structural Motifs as a Basis for Specificity
D.L. Smith and S.H. Nilar
Affiliation: Asuragen, Inc., 2150 Woodward St., Suite 100, Austin, TX, 78744, USA.
Mitogen-activated protein kinases (MAPKs) are key components of cellular signal transduction. It is the objective of this communication to demonstrate that insight into protein-protein interactions in the Common Docking motif of yeast mitogen-activated protein kinases can be obtained based on homology models. Homology models for four yeast MAPKs, FUS3, KSS1, HOG1 and MPK1 were built based on the X-ray structures of active and inactive rat ERK2. The structural motifs required for the basis of specificity were rationalized based on these structures.
Keywords: Homology, molecular modeling, common docking motif, yeast, mitogen-activated protein kinase, signal transduction
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