Homology Modeling Studies of Yeast Mitogen-Activated Protein Kinases (MAPKS): Structural Motifs as a Basis for Specificity

Author(s): D.L. Smith, S.H. Nilar.

Journal Name:Protein & Peptide Letters

Volume 17 , Issue 6 , 2010


Mitogen-activated protein kinases (MAPKs) are key components of cellular signal transduction. It is the objective of this communication to demonstrate that insight into protein-protein interactions in the Common Docking motif of yeast mitogen-activated protein kinases can be obtained based on homology models. Homology models for four yeast MAPKs, FUS3, KSS1, HOG1 and MPK1 were built based on the X-ray structures of active and inactive rat ERK2. The structural motifs required for the basis of specificity were rationalized based on these structures.

Keywords: Homology, molecular modeling, common docking motif, yeast, mitogen-activated protein kinase, signal transduction

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Article Details

Year: 2010
Page: [732 - 738]
Pages: 7
DOI: 10.2174/092986610791190327
Price: $58