EQCM Biosensors Based on DNA Aptamers and Antibodies for Rapid Detection of Prions

Author(s): T. Hianik, A. Porfireva, I. Grman, G. Evtugyn.

Journal Name:Protein & Peptide Letters

Volume 16 , Issue 4 , 2009

Abstract:

Novel affinity biosensors for detecting cellular prions, PrPC, based on DNA aptamers and antibodies immobilized onto the carbon nanotubes have been designed and compared in accordance with their binding ability and analytical performance. The biosensors allowed us to detect PrPC with the limits of detection of 20 to 50 pM.

Keywords: Prion proteins, DNA aptamers, antibodies, biosensor, multiwalled carbon nanotubes, electrochemical quartz crystal microbalance

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Article Details

VOLUME: 16
ISSUE: 4
Year: 2009
Page: [363 - 367]
Pages: 5
DOI: 10.2174/092986609787848090
Price: $58