Infectious Disorders - Drug Targets

(Formerly Current Drug Targets - Infectious Disorders)

Jean-Marc Sabatier  
Laboratoire ERT 62 'Ingénierie des peptides à visée thérapeutique' 
Université de la Méditerranée
Faculté de Médecine Nord
Boulevard Pierre Dramard
13916 - MARSEILLE, Cedex 20
France

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Antiviral Treatment of Chikungunya Virus Infection

Author(s): Xavier de Lamballerie, Laetitia Ninove and Remi N. Charrel

Affiliation: Unite des Virus Emergents, UMR190 IRD / Universite de la Mediterranee / Assistance Publique- Hopitaux de Marseille, Faculte de Medecine, 27 Bd. J. Moulin, 13005 Marseille, France.

Abstract:

Chikungunya virus is a typical emerging virus which has been responsible for several million cases of human infections since 2004. No antiviral treatment is currently available. The antimalarial chloroquine has been used in the past but recent studies suggest that it is not or poorly active in vivo. A number of tracks are currently under investigation (inhibition of viral enzymes, of virus entry or maturation, enhancement of immunological response) and new animal models have been made available, including a mouse model and a non-human primate model. We review here the main perspectives of chikungunya antiviral treatment.

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Article Details

VOLUME: 9
ISSUE: 2
Page: [101 - 104]
Pages: 4
DOI: 10.2174/187152609787847712