Generic placeholder image

Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Preparation and Structures of Isoindolone- or Pyrimidone-Condensed Heterocycles Containing a Hydroxy Group on a Cyclohexane or Norbornane Moiety

Author(s): Ferenc Miklos, Pal Sohar, Antal Csampai, Reijo Sillanpaa and Geza Stajer

Volume 6, Issue 3, 2009

Page: [252 - 257] Pages: 6

DOI: 10.2174/157017809787893136

Price: $65

Abstract

With DL-valinol, 3-amino-1-propanol and o-aminothiophenol, aroyl(bi/tri)cyclic lactones 1 and 2 were cyclized to isoindole- 4-6, 8, 9, pyrimidinone- 10 or thiazepine- 7 condensed heterocycles. The ketal lactone 3 furnished the benzthiazoloisoindole 9 and mixtures of epimeric hydroxyphthalazinoquinazolinones 11 and 12. The structures were established by means of 1H and 13C NMR spectroscopy and in some cases by X-ray crystallography.

Keywords: Cycloalkane lactones, Isoindolones, 1,3-oxazines, Thiazoles, Stereostructure, NMR, X-ray


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy