Solvent-Free Microwave-Assisted Synthesis of New 2-Aryl-Tetrahydroquinolines Using Three-Component Povarov Reaction

Author(s): Luis S. Astudillo, Margarita Gutierrez C., Hugo Gaete, Vladimir V. Kouznetsov, Carlos M. Melendez, J. Antonio Palenzuela, Gabriel Vallejos G..

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 3 , 2009

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Abstract:

A new series of 2-aryl-1,2,3,4-tetrahydroquinolines has been synthesized in good yields through a BiCl3- catalyzed three-component Povarov reaction (imino Diels-Alder cycloaddition) between anilines, benzaldehydes and Nvinylpyrrolidin- 2-one in MeCN. The same series has been prepared without solvent using microwave radiation, which resulted in better yields, a considerable decrease in reaction times and simplified workup.

Keywords: 2-Aryl-1,2,3,4-tetrahydroquinolines, microwave-heated three-component Povarov (imino Diels-Alder) reaction, dry media

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2009
Page: [208 - 212]
Pages: 5
DOI: 10.2174/157017809787893145
Price: $65

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