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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Solvent-Free Microwave-Assisted Synthesis of New 2-Aryl-Tetrahydroquinolines Using Three-Component Povarov Reaction

Author(s): Luis S. Astudillo, Margarita Gutierrez C., Hugo Gaete, Vladimir V. Kouznetsov, Carlos M. Melendez, J. Antonio Palenzuela and Gabriel Vallejos G.

Volume 6, Issue 3, 2009

Page: [208 - 212] Pages: 5

DOI: 10.2174/157017809787893145

Price: $65

Abstract

A new series of 2-aryl-1,2,3,4-tetrahydroquinolines has been synthesized in good yields through a BiCl3- catalyzed three-component Povarov reaction (imino Diels-Alder cycloaddition) between anilines, benzaldehydes and Nvinylpyrrolidin- 2-one in MeCN. The same series has been prepared without solvent using microwave radiation, which resulted in better yields, a considerable decrease in reaction times and simplified workup.

Keywords: 2-Aryl-1,2,3,4-tetrahydroquinolines, microwave-heated three-component Povarov (imino Diels-Alder) reaction, dry media


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