The Practical Synthesis of Double Axial Chiral Guanidines

Author(s): Qun-Sheng Guo, Da-Ming Du.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 3 , 2009

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Abstract:

Two novel double axial chiral guanidines were designed according to the concept of double axial chirality. The practical synthetic procedures from (S)-1,1-binaphthol have been developed. The title compounds were fully characterized by NMR, MS, IR and elemental analysis or HRMS. The two chiral guanidines can be interesting catalysts for asymmetric catalysis and preliminary asymmetric catalytic activity was investigated in Henry reaction and conjugate addition.

Keywords: Guanidine, chiral catalyst, organic base, synthesis

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2009
Page: [197 - 202]
Pages: 6
DOI: 10.2174/157017809787893028
Price: $65

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