Allosteric Transitions in Biological Nanomachines are Described by Robust Normal Modes of Elastic Networks

Author(s): Wenjun Zheng, Bernard R. Brooks, D. Thirumalai.

Journal Name: Current Protein & Peptide Science

Volume 10 , Issue 2 , 2009

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Abstract:

Allostery forms the basis of intra-molecular communications in various enzymes, however the underlying conformational changes are largely elusive. Recently, we have proposed to employ an elastic model based normal mode analysis to investigate the allosteric transitions in several molecular nanomachines (including myosin II, DNA polymerase and chaperonin GroEL). After combining with bioinformatics analysis of the evolutionary sequence variations, we have been able to identify the highly conserved and robust modes of collective motions that are capable of transmitting molecular signals over long distances.

Keywords: Allostery, chaperonin, elastic network model, myosin, normal mode analysis, polymerase

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2009
Page: [128 - 132]
Pages: 5
DOI: 10.2174/138920309787847608
Price: $58

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